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JCH-1 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK). It has been shown to effectively inhibit DNA-PK activity in both in vitro and in vivo studies. JCH-1 has also demonstrated promising anti-tumor activity in preclinical models, making it a potential candidate for cancer therapy.
One of the key features of JCH-1 is its ability to target DNA-PK, a critical component of the DNA damage response pathway. By inhibiting DNA-PK, JCH-1 can enhance the sensitivity of cancer cells to DNA-damaging agents such as chemotherapy and radiation therapy. This mechanism of action makes JCH-1 a promising candidate for combination therapy in the treatment of cancer.
In addition to its anti-tumor activity, JCH-1 has also been shown to have a favorable safety profile in preclinical studies. This suggests that JCH-1 may have the potential to be well-tolerated in patients, which is a crucial factor for the development of a new cancer therapy.
Overall, the preclinical data on JCH-1 support its potential as a novel and effective anti-cancer agent. Further studies are needed to evaluate its efficacy and safety in clinical trials, but the promising results thus far suggest that JCH-1 could be a valuable addition to the cancer therapy arsenal.
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